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Papers of the Week

Papers: 10 Dec 2022 - 16 Dec 2022

Animal Studies

2022 Dec 09

Br J Pharmacol

Non-neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats.


De Logu F, De Siena G, Landini L, Marini M, Souza Monteiro de Araujo D, Albanese V, Preti D, Romitelli A, Chieca M, Titiz M, Iannone LF, Geppetti P, Nassini R
Br J Pharmacol. 2022 Dec 09.
PMID: 36494916.


The proalgesic transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons, has been implicated in various pain models in mice. However, evidence in rats indicates that TRPA1 conveys nociceptive signals elicited by channel activators, but not those associated with tissue inflammation or nerve injury. Here, in rats, we explored the TRPA1 role in mechanical allodynia associated with stimulation of peptidergic primary sensory neurons (neurogenic inflammation) and moderate (partial sciatic nerve ligation, pSNL) or severe (chronic constriction injury, CCI) sciatic nerve injury.