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Papers of the Week

Papers: 10 Dec 2022 - 16 Dec 2022

Pharmacology/Drug Development

2022 Dec 07

Pain Pract

Efficacy and Safety of Twice-Daily Tramadol Hydrochloride Bilayer Sustained-Release Tablets with an Immediate Release Component for Postherpetic Neuralgia: Results of a Phase III, Randomized, Double-Blind, Placebo-Controlled, Treatment-Withdrawal Study.


We investigated the efficacy and safety of twice-daily bilayer sustained-release tramadol hydrochloride tablets (35% immediate-release; 65% sustained-release) in patients with postherpetic neuralgia.