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Papers of the Week

2022 Dec 02

Medicine (Baltimore)



Two-year follow-up of a young male with possible acute hemorrhagic leukoencephalitis: A case report.


Wu C, Zhang W, Jiao Y, Dong M, Zhou H, Lv Y, Yang J
Medicine (Baltimore). 2022 Dec 02; 101(48):e32073.
PMID: 36482561.


Acute hemorrhagic leukoencephalitis (AHLE) is a rare but fetal fulminant demyelinating disease of unknown etiology. It is commonly regarded as a severe variant of acute demyelinating encephalomyelitis (ADEM). Its rapid clinical deterioration and high mortality appeal to clinicians to attach importance to early diagnosis. Immunosuppressive therapy is the main management to attenuate the autoimmune process, but with varied response and prognosis.