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Papers of the Week

2022 Dec 09

Chem Biodivers

The antinociceptive effect of a hydroalcoholic extract of Polygala altomontana and its chemical profile using UPLC-ESI-QTOF-HR-MS.


Sandjo L P, Pradi L, Andrade TES, Lacerda JWF, Karvat J, Beppler LM, Tizziani T, Santos ARS, Sandjo LP
Chem Biodivers. 2022 Dec 09.
PMID: 36490384.


The hydroalcoholic extract of Polygala altomontana (30, 100, and 300 mg/kg, i.g.) showed a dose-dependent antinociceptive action during the inflammatory phase of the formalin test. In addition, the preparation (30 and 300 mg/kg, i.g.) showed anti-hyperalgesic action when tested on a mechanical nociception model. UPLC-ESI-QTOF-MS data indicated the active extract contained phenylpropanoid sucrose esters, glycosylated quercetin derivatives, styrylpyrones, and coumarins. Some identified compounds, including styrylpyrones and coumarins, have previously demonstrated antinociceptive action. The results also show that P. altomontana shows potential for developing pain-relieving herbal remedies and drugs.