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Papers of the Week


Papers: 3 Dec 2022 - 9 Dec 2022


2022 Dec 07


Br J Pharmacol

Sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors.

Authors

Ruiz-Cantero CM, Cortés-Montero E, Jain A, Montilla-García Á, Bravo-Caparrós I, Shim J, Sánchez-Blázquez P, Woolf CJ, Baeyens JM, Cobos EJ
Br J Pharmacol. 2022 Dec 07.
PMID: 36478100.

Abstract

Peripheral sensitization contributes to pathological pain. While prostaglandin E2 (PGE2) and nerve growth factor (NGF) sensitize peptidergic C-nociceptors (TRPV1+), glial cell line-derived neurotrophic factor (GDNF) sensitizes non-peptidergic C-neurons (IB4+). Sigma-1 receptor (σ1R) is a Ca -sensing chaperone known to modulate analgesia induced by opioid drugs. This receptor binds both to TRPV1 and the μ-opioid receptor (MOPr), although the functional repercussions of these physical interactions in peripheral sensitization are unknown.