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Papers of the Week

Papers: 3 Dec 2022 - 9 Dec 2022

2022 Sep

Osteoarthr Cartil Open



CD90-positive stromal cells associate with inflammatory and fibrotic changes in modic changes.


Dudli S, Karol A, Giudici L, Heggli I, Laux CJ, Spirig JM, Wanivenhaus F, Betz M, Germann C, Farshad-Amacker N, Brunner F, Distler O, Farshad M
Osteoarthr Cartil Open. 2022 Sep; 4(3):100287.
PMID: 36474945.


Modic changes (MC) are vertebral bone marrow lesions seen on magnetic resonance images, that associate with disc degeneration and low back pain (LBP). Few studies described MC histopathology qualitatively based on a few patient samples. CD90-positive bone marrow stromal cells were shown to be pro-fibrotic in MC. We aimed to provide the first semi-quantitative histomorphometric analysis of MC bone marrow. We hypothesized a role of CD90-positive cells in MC pathomechanisms.