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Papers of the Week

2022 Dec 06

Int J Neuropsychopharmacol

Inflammation and blood-brain-barrier in depression – interaction of CLDN5 and IL6 gene variants in stress-induced depression.


Gal Z, Torok D, Gonda X, Eszlari N, Anderson I M, William Deakin J F, Juhasz G, Bagdy G, Petschner P
Int J Neuropsychopharmacol. 2022 Dec 06.
PMID: 36472886.


Evidence from rodents indicated that after recent stress, reduced expression of tight junction protein claudin-5 may weaken the blood-brain barrier and allow interleukin-6 to induce depressive symptoms. Our aims were to prove this pathomechanism in humans.