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Papers of the Week

Papers: 3 Dec 2022 - 9 Dec 2022

2022 Dec 03

Osteoarthritis Cartilage

Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients.


Tellegen AR, Rudnik-Jansen I, Utomo L, Versteeg S, Beukers M, Maarschalkerweerd R, van Zuilen D, van Klaveren NJ, Houben K, Teske E, René van Weeren P, Karssemakers-Degen N, Mihov G, Thies J, Eijkelkamp N, Creemers LB, Meij BP, Tryfonidou MA
Osteoarthritis Cartilage. 2022 Dec 03.
PMID: 36473675.


Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for OA. The aim of this study was to investigate the safety and efficacy of an intra-articular sustained release formulation containing celecoxib (CXB), a COX-2 selective inhibitor.