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Papers of the Week

2022 Dec 07

J Med Case Rep



Myositis ossificans circumscripta after surgery and radiotherapy and during sunitinib treatment: a case report.


Cren P-Y, Penel N, Cordoba A, Decanter G, Gaboriau L, Ben Haj Amor M
J Med Case Rep. 2022 Dec 07; 16(1):454.
PMID: 36474288.


Myositis ossificans circumscripta is a self-limiting, benign, ossifying lesion that can affect any type of soft tissue. It is most commonly found in muscles as a solitary lesion. A history of recent trauma has been reported in approximately 50% of cases. Clinically, MOC presents as a painful swelling, which rapidly increases in size. The pain and inflammatory symptoms spontaneously disappear after approximately 2-6 weeks, and the mass stabilizes or decreases. Radiologically, myositis ossificans circumscripta can be divided into two phases. The first is the acute phase, which is followed by the mature phase 2-6 weeks later. During the acute phase, the radiological aspect does not show any specific abnormality. In the mature phase, plain radiographs and computed tomography show blurred calcifications around a hypodense center. We describe here the first case of myositis ossificans circumscripta, with appropriate follow-up, occurring during sunitinib exposure.