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Papers of the Week

Papers: 3 Dec 2022 - 9 Dec 2022

2022 Nov

Ann Transl Med



TLR-activated mesenchymal stromal cell therapy and antibiotics to treat multi-drug resistant septic arthritis in an equine model.


Pezzanite LM, Chow L, Phillips J, Griffenhagen GM, Moore RA, Schaer TP, Engiles JB, Werpy N, Gilbertie J, Schnabel LV, Antczak D, Miller D, Dow S, Goodrich LR
Ann Transl Med. 2022 Nov; 10(21):1157.
PMID: 36467344.


Rapid development of antibiotic resistance necessitates advancement of novel therapeutic strategies to treat infection. Mesenchymal stromal cells (MSC) possess antimicrobial and immunomodulatory properties, mediated through antimicrobial peptide secretion and recruitment of innate immune cells including neutrophils and monocytes. TLR-3 activation of human, canine and equine MSC has been shown to enhance bacterial killing and clearance , in rodent biofilm infection models and dogs with spontaneous multi-drug-resistant infections. The objective of this study was to determine if intra-articular (IA) TLR-3-activated MSC with antibiotics improved clinical parameters and reduced bacterial counts and inflammatory cytokine concentrations in synovial fluid (SF) of horses with induced septic arthritis.