I am a
Home I AM A Search Login

Papers of the Week

Papers: 3 Dec 2022 - 9 Dec 2022

2022 Dec 05

J Headache Pain



PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.


Guo S, Ernstsen C, Hay-Schmidt A, Ashina M, Olesen J, Christensen S L
J Headache Pain. 2022 Dec 05; 23(1):155.
PMID: 36471250.


Calcitonin gene-related peptide (CGRP) antagonizing drugs represents the most important advance in migraine therapy for decades. However, these new drugs are only effective in 50-60% of patients. Recent studies have shown that the pituitary adenylate cyclase-activating peptide (PACAP38) pathway is independent from the CGRP signaling pathway. Here, we investigate PACAP38 signaling pathways in relation to glyceryl trinitrate (GTN), levcromakalim and sumatriptan.