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Papers of the Week

2022 Dec 03

Alcohol Clin Exp Res

Influence of early-life adversity on responses to acute and chronic ethanol in female mice.


Okhuarobo A, Angelo M, Bolton JL, Lopez C, Igbe I, Baram TZ, Contet C
Alcohol Clin Exp Res. 2022 Dec 03.
PMID: 36462937.


Stressful early-life experiences increase the risk of developing an alcohol use disorder. We had previously found that male C57BL/6J mice reared under limited bedding and nesting (LBN) conditions, a model of early-life adversity, escalate their ethanol intake in limited-access two-bottle choice (2BC) sessions faster than control (CTL)-reared counterparts when exposed to chronic intermittent ethanol (CIE) vapor inhalation. However, the alcohol consumption of female littermates was not affected by LBN or CIE. In the present study, we sought to determine whether this phenotype reflected a general insensitivity of female mice to the influence of early life stress on alcohol responses.