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Papers of the Week

Papers: 26 Nov 2022 - 2 Dec 2022

Pharmacology/Drug Development

2022 Nov-Dec

Pain Rep



Characterizing DNA methylation in prescription opioid users with chronic musculoskeletal pain.


Sheikh S, Smotherman C, Patel M, Langaee T, Wang D, Swaray E, Velasquez E, Schmidt SOF, Hendry P, Cavallari LH, Fillingim RB
Pain Rep. 2022 Nov-Dec; 7(6):e1046.
PMID: 36447952.


Many patients with chronic pain use prescription opioids. Epigenetic modification of the μ-opioid receptor 1 () gene, which codes for the target protein of opioids, may influence vulnerability to opioid abuse and response to opioid pharmacotherapy, potentially affecting pain outcomes.