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Papers of the Week
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents.
Abstract
Patients suffering from trigeminal neuralgia (TN) are often accompanied by anxiety and depression. Microglia-mediated neuroinflammation is involved in the development of neuropathic pain and anxiodepression pathogenesis. Whether and how microglia are involved in TN-induced anxiodepression remains unclear.