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Papers of the Week

Papers: 26 Nov 2022 - 2 Dec 2022

Animal Studies

2022 Nov 28

Br J Pharmacol

Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents.


Chen L-Q, Lv X-J, Guo Q-H, Lv S-S, Lv N, Xu W-D, Yu J, Zhang Y-Q
Br J Pharmacol. 2022 Nov 28.
PMID: 36443951.


Patients suffering from trigeminal neuralgia (TN) are often accompanied by anxiety and depression. Microglia-mediated neuroinflammation is involved in the development of neuropathic pain and anxiodepression pathogenesis. Whether and how microglia are involved in TN-induced anxiodepression remains unclear.