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Papers of the Week

2022 Nov 29

Circ Res

Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression.


Cui K, Gao X, Wang B, Wu H, Arulsamy K, Dong Y, Xiao Y, Jiang X, Malovichko MV, Li K, Peng Q, Wei Lu Y, Zhu B, Zheng R, Wong S, Cowan DB, Linton MR, Srivastava S, Shi J, Chen K, et al.
Circ Res. 2022 Nov 29.
PMID: 36444722.


Excess cholesterol accumulation in lesional macrophages elicits complex responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of atherosclerosis; however, the underlying mechanism and therapeutic potential of targeting Epsins remains unknown. In this study, we determined the role of Epsins in macrophage-mediated metabolic regulation. We then developed an innovative method to therapeutically target macrophage Epsins with specially designed S2P-conjugated lipid nanoparticles, which encapsulate small-interfering RNAs to suppress Epsins.