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Papers of the Week

2022 Nov 29

BMJ Open



Pain predict genetics: protocol for a prospective observational study of clinical and genetic factors to predict the development of postoperative pain.


Li S, Van Boekel RLM, van den Heuvel SAS, Coenen MJH, Vissers KCP
BMJ Open. 2022 Nov 29; 12(11):e066134.
PMID: 36446453.


Postoperative pain remains a challenging medical condition impacting the quality of life of every patient. Although several predictive factors for postoperative pain have been identified, an adequate prediction of postoperative pain in patients at risk has not been achieved yet.The primary objective of this study is to identify specific genetic risk factors for the development of acute and chronic postoperative pain to construct a prediction model facilitating a more personalised postoperative pain management for each individual. The secondary objectives are to build a databank enabling researchers to identify other risk factors for postoperative pain, for instance, demographic and clinical outcome indicators; provide insight into (genetic) factors that predict pharmacological pain relief; investigate the relationship between acute and chronic postoperative pain.