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Front Pharmacol


From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders.


Norouzkhani N, Karimi A G, Badami N, Jalalifar E, Mahmoudvand B, Ansari A, Pakrou Sariyarighan N, Alijanzadeh D, Aghakhani S, Shayestehmehr R, Arzaghi M, Sheikh Z, Salami Y, Marabi M H, Abdi A, Deravi N
Front Pharmacol. 2022; 13:960037.
PMID: 36438833.


Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These days, studies on plant efficacy in traditional medicine are being conducted because herbal medicine is affordable, safe, and culturally acceptable and easily accessible. The Indian traditional medicine system called Ayurveda uses several herbs and medicinal plants to treat various disorders including neurological disorders. This review aims to summarize the data on the neuroprotective potential of the following common Indian spices widely used in Ayurveda: cumin ( (L.), Apiaceae), black cumin ( (L.), Ranunculaceae), black pepper ( (L.), Piperaceae), curry leaf tree ( (L.), Spreng Rutaceae), fenugreek ( (L.), Fabaceae), fennel ( Mill, Apiaceae), cardamom ( (L.) Maton, Zingiberaceae), cloves ( (L.) Merr. & L.M.Perry, Myrtaceae), and coriander ( (L.), Apiaceae) in age-related neurological disorders.