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Ther Adv Musculoskelet Dis


Higher body mass index is associated with a lower iloprost infusion rate tolerance and higher iloprost-related adverse events in patients with systemic sclerosis.


Bixio R, Adami G, Bertoldo E, Giollo A, Morciano A, Bertelle D, Orsolini G, Idolazzi L, Rossini M, Viapiana O
Ther Adv Musculoskelet Dis. 2022; 14:1759720X221137125.
PMID: 36439640.


Systemic sclerosis (SSc) is an autoimmune disease characterized by vasospasm and microvascular involvement. Iloprost (ILO), a prostaglandin analogous, is used for the treatment of SSc-related Raynaud's phenomenon and digital ulcers. The suggested dose is 0.5-2 ng/kg/min for 6-8 h, and the maximum dose is decided upon the patient's tolerance.