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Papers of the Week

2022 Nov 28

J Travel Med

Should we treat Blastocystis sp.? A double-blind placebo-controlled randomized pilot trial.


Cobuccio L G, Laurent M, Gardiol C, Wampfler R, Poppert S, Senn N, Eperon G, Genton B, Locatelli I, Vallière S
J Travel Med. 2022 Nov 28.
PMID: 36440639.


Blastocystis sp. is a worldwide-distributed protist colonizing the guts of humans and a great variety of animals. It is unclear whether it is just a commensal or an infectious parasite that prompts eradication.The main objective of this study was to evaluate the usefulness of metronidazole in patients with gastrointestinal symptoms harbouring only Blastocystis sp. In addition, we explored whether Blastocystis subtype or concomitant parasitic infection detected by polymerase chain reaction (PCR) may influence treatment outcome.