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Papers of the Week

2022 Nov 28

Clin Exp Pharmacol Physiol

Oral pregabalin is effective as preemptive analgesia in abdominal hysterectomy – a randomized controlled trial.


da Silva F G, Podestá M H M C, Silva T C, de Barros C M, de Carvalho B F V, Dos Reis T M, Espósito M C, de Oliveira Marrafon D A F, Nogueira D A, Diwan S, Ceron C S, Torres L H
Clin Exp Pharmacol Physiol. 2022 Nov 28.
PMID: 36440985.


Postoperative pain is one of the main negative symptoms resulting from surgery and the use of new methods to control this symptom is of ever-increasing relevance. Opioid-sparing strategies, such as multimodal analgesia, are trends in this scenario. Pregabalin is a well-established treatment for neuropathic pain; however, it is still controversial in the surgical context for postoperative analgesia. The aim of this study was to investigate the effect of pregabalin on postoperative analgesia in patients undergoing abdominal hysterectomy.