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Papers of the Week

2022 Nov 28

PLoS Negl Trop Dis



Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality.


Alam AM, Gillespie CS, Goodall J, Damodar T, Turtle L, Vasanthapuram R, Solomon T, Michael BD
PLoS Negl Trop Dis. 2022 Nov 28; 16(11):e0010952.
PMID: 36441812.


Scrub typhus has become a leading cause of central nervous system (CNS) infection in endemic regions. As a treatable condition, prompt recognition is vital. However, few studies have focused on describing the symptomology and outcomes of neurological scrub typhus infection. We conducted a systematic review and meta-analysis to report the clinical features and case fatality ratio (CFR) in patients with CNS scrub typhus infection.