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Papers of the Week

2022 Nov 26

J Transl Med



Unilateral acute lung injury in pig: a promising animal model.


Geilen J, Kainz M, Zapletal B, Geleff S, Wisser W, Bohle B, Schweiger T, Schultz MJ, Tschernko E
J Transl Med. 2022 Nov 26; 20(1):548.
PMID: 36435803.


Acute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating the strictly unilateral nature and severity of lung injury by the key parameters characterizing ALI as defined by the American Thoracic Society (ATS). Thus, the use of unilateral ALI remained rare despite the innovative approach. Therefore, we developed a unilateral model of ALI and focused on the crucial parameters characterizing ALI. This model can serve for direct comparisons between the injured and intact lungs within single animals, thus, reducing the number of animals required for valid experimental conclusions.