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Papers of the Week

2022 Sep 19

J Integr Neurosci



Triptolide Alleviates Neuropathic Pain by Inhibiting the Activation of Microglial Toll-Like Receptor 3.


Zhang Z-Q, Ji S-M, Yang L-Y, Mei X-P
J Integr Neurosci. 2022 Sep 19; 21(6):150.
PMID: 36424741.


Current data indicates the incidence of neuropathic pain after surgical nerve injury is as high as 50%, thus representing a major problem for patients and for the medical system. Triptolide, a traditional Chinese herb, has anti-inflammatory effects on various neurodegenerative and neuroinflammatory diseases. This agent also reduces peripheral nerve injury-induced neuropathic pain, although the mechanism underlying this effect is still unknown.