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Papers of the Week
Risk of vaso-occlusive episode in patients with sickle cell disease exposed to systemic corticosteroids: a comprehensive review.
Abstract
Sickle cell disease (SCD) is the most frequent inherited disorder in the world. It is the consequence of a single amino acid mutation on beta-globin chain, leading to red blood cells deformation, haemolysis and chronic inflammation. Clinical consequences are vaso-occlusives crisis, acute chest syndrome, thrombosis, infection and chronic endothelial lesions.