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Papers of the Week

Papers: 19 Nov 2022 - 25 Nov 2022

2022 Nov 14

Clin Pract



Dextrose Prolotherapy for Symptomatic Grade IV Knee Osteoarthritis: A Pilot Study of Early and Longer-Term Analgesia and Pain-Specific Cytokine Concentrations.


Topol G A, Pestalardo I G, Reeves K D, Elias F, Steinmetz NJ, Cheng A-L, Rabago D
Clin Pract. 2022 Nov 14; 12(6):926-938.
PMID: 36412676.


Neurocytokines may upregulate or downregulate neuropathic pain. We hypothesized that dextrose (D-glucose) injections for therapeutic purposes (dextrose prolotherapy: DPT) in painful knee osteoarthritis (KOA) would favorably affect synovial-fluid neurocytokine concentrations.