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Papers of the Week

Papers: 19 Nov 2022 - 25 Nov 2022

2022 Nov 19

BMC Genomics



Multi-omics to predict changes during cold pressor test.


Kogelman LJA, Ernst M, Falkenberg K, Mazzoni G, Courraud J, Lundgren L P, Laursen S S, Cohen A, Olesen J, Hansen T F
BMC Genomics. 2022 Nov 19; 23(1):759.
PMID: 36402977.


The cold pressor test (CPT) is a widely used pain provocation test to investigate both pain tolerance and cardiovascular responses. We hypothesize, that performing multi-omic analyses during CPT gives the opportunity to home in on molecular mechanisms involved. Twenty-two females were phenotypically assessed before and after a CPT, and blood samples were taken. RNA-Sequencing, steroid profiling and untargeted metabolomics were performed. Each 'omic level was analyzed separately at both single-feature and systems-level (principal component [PCA] and partial least squares [PLS] regression analysis) and all 'omic levels were combined using an integrative multi-omics approach, all using the paired-sample design.