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Papers of the Week

Papers: 12 Nov 2022 - 18 Nov 2022

Pharmacology/Drug Development

2022 Nov 16

Immunopharmacol Immunotoxicol

Morphine upregulates Toll-like receptor 4 expression and promotes melanomas in mice.


Vaseghi G, Ghasemi A, Laher I, Alaei HA, Dana N, Naji Esfahani H, Javanmard S H
Immunopharmacol Immunotoxicol. 2022 Nov 16:1-8.
PMID: 36382834.


Morphine and other opioids are used to manage cancer-related pain; however, the role of these drugs in cancer progression remains controversial. Emerging evidence indicates that morphine can activate Toll-like receptor 4 (TLR4) and its signaling pathways, by the way the activation and expression of TLR4 can promote melanoma. In this study, we investigated the effects of morphine on the expression of TLR4 and promotion of melanoma in mice.