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Papers of the Week

Papers: 12 Nov 2022 - 18 Nov 2022


J Inflamm Res


Sympathectomy Ameliorates CFA-Induced Mechanical Allodynia via Modulating Phenotype of Macrophages in Sensory Ganglion in Mice.


Mai L, Jia S, Liu Q, Chu Y, Liu J, Yang S, Huang F, Fan W
J Inflamm Res. 2022; 15:6263-6274.
PMID: 36386581.


The sympathetic nervous system (SNS) is suggested to be involved in some forms of pain, but the mechanisms of which are incompletely known. Moreover, there is a lack of information on the regulatory role of the SNS on macrophages in sensory ganglion, which plays an important role in pain development. The present study aims to investigate the effects of the SNS on orofacial inflammatory pain and examine, if any, how the SNS influences trigeminal ganglion (TG) macrophage responses.