I am a
Home I AM A Search Login

Papers of the Week

Papers: 12 Nov 2022 - 18 Nov 2022

Animal Studies, Pharmacology/Drug Development

2022 Nov

Pain Physician



The Involvement of CaV1.2 in Estrogenic Modulation of Morphine Antinociception in Rats Under Uterine Cervix Pain.


Sun L-H, Xu Q, Jin L, Jin L-D, Chen Q, Wu H, Chen X-Z
Pain Physician. 2022 Nov; 25(8):E1239-E1248.
PMID: 36375196.


Morphine is one of the preferred drugs for the clinical treatment of pain. Both clinical and preclinical studies have reported sexual dimorphism in morphine analgesia. Different circulating levels of estrogen could be involved in sex differences in response to morphine analgesia. In our previous research, we found that capsaicin injection into the cervix of rats caused acute visceral pain that could be relieved by morphine. The role of estrogen in morphine analgesia in rats under uterine cervix pain and its underlying mechanisms remain to be explored.