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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.

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Papers: 5 Nov 2022 - 11 Nov 2022


Animal Studies


2022 Nov 07


BMC Musculoskelet Disord


http://www.ncbi.nlm.nih.gov/pubmed/36344944?dopt=Abstract


23


1

Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.

Authors

Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model.
Arai T, Suzuki-Narita M, Takeuchi J, Tajiri I, Inage K, Kawarai Y, Eguchi Y, Shiga Y, Hozumi T, Kim G, Tsuchiya R, Otagiri T, Mukaihata T, Hishiya T, Toshi N, Okuyama K, Tokeshi S, Furuya T, Maki S, Matsuura Y, et al.
BMC Musculoskelet Disord. 2022 Nov 07; 23(1):960.
PMID: 36344944.

Abstract

Diclofenac etalhyaluronate (DF-HA) is a recently developed analgesic conjugate of diclofenac and hyaluronic acid that has analgesic and anti-inflammatory effects on acute arthritis. In this study, we investigated its analgesic effect on osteoarthritis, using a rat model of monoiodoacetate (MIA).
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