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Papers of the Week

Papers: 5 Nov 2022 - 11 Nov 2022

Pharmacology/Drug Development

2022 Nov 08

Inflamm Res

Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain.


Zhang Y, Wang W, Gong Z, Peng Y, Li X, Zhang Z, Zhang X, You X, Wu J
Inflamm Res. 2022 Nov 08.
PMID: 36346430.


Neuroinflammation in the peripheral nervous system has been linked to cancer metastasis-induced bone pain. The stimulator of interferon genes (STING), an innate immune sensor for cytosolic DNA, plays an important role in inflammation and cancer metastasis and is reported to be a critical regulator of nociception. Here, we examined the role of STING in primary nociceptive neurons and chronic pain to determine if it could be a new target for treating bone cancer pain (BCP).