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Papers of the Week

2023 Jan

Crit Care Clin



Neuropharmacology in the Intensive Care Unit.


Ammar A, Ammar MA, Tesoro EP
Crit Care Clin. 2023 Jan; 39(1):171-213.
PMID: 36333031.


Clinicians must individualize pharmacotherapy for patients with acute neurological injury based on multiple factors, including age, comorbidities, and chronic medication use. Many pharmacokinetic and pharmacodynamic properties are altered during acute illness, particularly absorption, distribution, metabolism, and elimination, which may result in loss of drug effect or toxicity. This article provides clinicians with general pharmacologic knowledge of the following drug regimens commonly prescribed to neurocritically ill adults: sedatives, analgesics, osmotherapy, antiseizure medications, antishivering agents, vasoactive agents, and antithrombotic reversal agents.