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Papers of the Week

2022 Nov 04

BMC Pediatr



A toddler with an unusually severe polyarticular arthritis and a lung involvement: a case report.


Basile P, Gortani G, Taddio A, Pastore S, Corona F, Tesser A, Barbi E, Tommasini A
BMC Pediatr. 2022 Nov 04; 22(1):639.
PMID: 36333696.


COPA syndrome is a rare hereditary inflammatory disease caused by mutations in the gene encoding the coatomer protein subunit alpha, causing excessive production of type I interferon. This case is a reminder for the general paediatrician, highlighting the relevance of the association between arthritis and lung involvement in toddlers.