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Papers of the Week

Papers: 5 Nov 2022 - 11 Nov 2022

Pharmacology/Drug Development


J Pain Res


Intravenous Lidocaine for Treatment of Chronic Pain: A Retrospective Cohort Study.


Horvat S, Staffhorst B, Cobben J-HMG
J Pain Res. 2022; 15:3459-3467.
PMID: 36329833.


Neuropathic pain is a widespread problem with a big impact on quality of life. The currently used drug regimens are often insufficiently effective or cause – sometimes unacceptable – side effects. Intravenous lidocaine could be an alternative treatment, by blocking spontaneous depolarization and hyperexcitability in upregulated sodium channels in nociceptors. Research so far has shown varying results but the treatment protocols differed a lot and follow-up was usually short. In our hospital, lidocaine infusions have been applied for many years in a unique treatment protocol consisting of a relatively high dose of lidocaine (1000 mg) administered over 25 hours. Our aim is to share information on both the efficacy and safety of this treatment schedule.