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Papers of the Week

2022 Oct 31

Int J Stem Cells

Wedelolactone Promotes the Chondrogenic Differentiation of Mesenchymal Stem Cells by Suppressing EZH2.


Qin W, Yang L, Chen X, Ye S, Liu A, Chen D, Hu K
Int J Stem Cells. 2022 Oct 31.
PMID: 36310024.


Osteoarthritis (OA) is a degenerative disease that leads to the progressive destruction of articular cartilage. Current clinical therapeutic strategies are moderately effective at relieving OA-associated pain but cannot induce chondrocyte differentiation or achieve cartilage regeneration. We investigated the ability of wedelolactone, a biologically active natural product that occurs in Eclipta alba (false daisy), to promote chondrogenic differentiation.