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Papers of the Week

2022 Oct 29

Ann Pharmacother

Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients.


Habeeb EA, Tran LK, Goodberlet MZ, Lupi KE, DeGrado JR, Dube KM
Ann Pharmacother. 2022 Oct 29:10600280221132851.
PMID: 36314271.


Opioid-induced constipation (OIC) may occur in up to 81% of critically ill patients and can lead to many complications. Opioid antagonists are a reasonable approach and may be used for managing OIC.