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Papers of the Week

Papers: 29 Oct 2022 - 4 Nov 2022

Animal Studies

2022 Oct 29

J Neuroinflammation



Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain.


Wang L, Gunduz MA, Semeano AT, Yılmaz EC, Alanazi FAH, Imir OB, Yener U, Arbelaez CA, Usuga E, Teng YD
J Neuroinflammation. 2022 Oct 29; 19(1):264.
PMID: 36309729.


People with spinal cord injury (SCI) frequently develop neuropathic pain (NP) that worsens disability and diminishes rehabilitation efficacy. Chronic NP is presently incurable due to poor understanding of underlying mechanisms. We hypothesized that multilocus neuroinflammation (NIF) might be a driver of SCI NP, and tested it by investigating whether NP coexisted with central NIF, neurotransmission (NTM), neuromodulation (NML) and neuroplasticity (NPL) changes post-SCI.