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Papers of the Week

Papers: 29 Oct 2022 - 4 Nov 2022

2022 Oct 29

Psychopharmacology (Berl)

Respiratory effects of oral mitragynine and oxycodone in a rodent model.


Henningfield JE, Rodricks JV, Magnuson AM, Huestis MA
Psychopharmacology (Berl). 2022 Oct 29.
PMID: 36308562.


Kratom derives from Mitragyna speciosa (Korth.), a tropical tree in the genus Mitragyna (Rubiaceae) that also includes the coffee tree. Kratom leaf powders, tea-like decoctions, and commercial extracts are taken orally, primarily for health and well-being by millions of people globally. Others take kratom to eliminate opioid use for analgesia and manage opioid withdrawal and use disorder. There is debate over the possible respiratory depressant overdose risk of the primary active alkaloid, mitragynine, a partial μ-opioid receptor agonist, that does not signal through ß-arrestin, the primary opioid respiratory depressant pathway.