Septic emboli induce two insults – firstly, the infectious insult, which causes inflammation and increases the potential for abscess formation, and secondly, the early embolic/ischemic insult brought on by arterial blockage and infarction. Pulmonary embolism is the second leading cause of cardiovascular disease-associated death, right after cardiovascular events. The sequelae of venous thromboembolism include post-thrombotic syndrome and chronic thromboembolic pulmonary hypertension (CTEPH). The pathophysiological characteristics of inflammation, hypercoagulability, and endothelial damage are the three components of Virchow's triad, which are mirrored by the risk factors for both diseases. The screening of patients for whom venous thromboembolism can be ruled out with a positive plasma D-dimer test result is made easier by clinical probability evaluation. To confirm the diagnosis, compression ultrasonography that displays deep vein thrombosis or a chest CT that reveals pulmonary embolism have been frequently employed. We report a case of a young male who presented with sudden onset pain and swelling in the left lower limb and chest following an intramuscular injection which further resulted in pulmonary thromboembolism.