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Papers of the Week

2022 Oct 27

J Perioper Pract

Comparison of fentanyl and nalbuphine as adjuvants to intrathecal 0.5% bupivacaine in lower limb surgeries: A randomised double-blind prospective study.


Geetha S, Rudrakshala S, Kar P, Durga P, Charitha K
J Perioper Pract. 2022 Oct 27:17504589221119907.
PMID: 36301019.


Local anaesthetics used in spinal anaesthesia have a limited duration of action. To prolong postoperative analgesia, adjuvants, mainly opioids, are used. As µ agonist drugs have side effects, other receptor agonists are considered. Nalbuphine is a safe and effective kappa agonist adjuvant.