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Papers of the Week

2022 Oct 26

BMJ Open



Ten sessions of transcranial direct current stimulation for chronic chikungunya arthralgia: study protocol for a randomised clinical trial.


do Nascimento A S, Cavalcante A F L, Araújo T A B D, da Silva J D D, Silva-Filho E, Okano A, Peroni Gualdi L, Pegado R
BMJ Open. 2022 Oct 26; 12(10):e065387.
PMID: 36288831.


The chikungunya virus infection is still an epidemic in Brazil with an incidence of 59.4 cases per 100 000 in the Northeast region. More than 60% of the patients present relapsing and remitting chronic arthralgia with debilitating pain lasting for years. Transcranial direct current stimulation (tDCS) appears promising as a novel neuromodulation approach for pain-related networks to alleviate pain in several pain syndromes. Our objective is to evaluate the effectiveness of tDCS (C3/Fp2 montage) on pain, muscle strength, functionality and quality of life in chronic arthralgia.