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Papers of the Week

2022 Oct 23

Chin Med



Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects.


Boonrueng P, Dasuni Wasana P W, Dasuni Wasana P W, Vajragupta O, Rojsitthisak P, Towiwat P
Chin Med. 2022 Oct 23; 17(1):119.
PMID: 36274168.


Curcumin and piperine are major bioactive compounds of Curcuma longa and Piper nigrum, widely consumed as spices and flock medicine. The combinational use of these plants is a common practice in Southeast Asia. Synergism between curcumin and piperine has been found in several animal models but not in periodontal disease and diabetes, and the antinociceptive interaction is still unknown. Hence, the present study aimed to assess the interaction between curcumin and piperine in pain and its potential CNS side effect profile.