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Papers of the Week


Papers: 22 Oct 2022 - 28 Oct 2022

PAIN TYPE:
Migraine/Headache


2022 Oct 21


Cephalalgia

Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache.

Authors

Schoenen J, Snoer A H, Brandt RB, Fronczek R, Wei DY, Chung C-S, Diener H-C, Dodick DW, Fontaine D, Goadsby PJ, Matharu M S, May A, McGinley JS, Tepper SJ, Jensen R H, Ferrari MD
Cephalalgia. 2022 Oct 21:3331024221120266.
PMID: 36268950.

Abstract

In 1995, a committee of the International Headache Society developed and published the first edition of the These have not been revised. With the emergence of new medications, neuromodulation devices and trial designs, an updated version of the International Headache Society is warranted. Given the scarcity of evidence-based data for cluster headache therapies, the update is largely consensus-based, but takes into account lessons learned from recent trials and demands by patients. It is intended to apply to both drug and neuromodulation treatments, with specific proposals for the latter when needed. The primary objective is to propose a template for designing high quality, state-of-the-art, controlled clinical trials of acute and preventive treatments in episodic and chronic cluster headache. The recommendations should not be regarded as dogma and alternative solutions to particular methodological problems should be explored in the future and scientifically validated.