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Papers of the Week

2022 Oct

Laryngoscope Investig Otolaryngol



Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil-induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial.


Hadavi S M R, Eghbal M H, Kaboodkhani R, Alizadeh N, Sahmeddini M A
Laryngoscope Investig Otolaryngol. 2022 Oct; 7(5):1360-1366.
PMID: 36258848.


Remifentanil is usually used for controlled hypotension during rhinoplasty under general anesthesia (G/A). One of the complications of the remifentanil is postoperative hyperalgesia. In this study, we compare the effectiveness of pregabalin with that of Mg sulfate in postoperative remifentanil-induced hyperalgesia prevention.