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Papers of the Week

2022 Oct 20

Paediatr Anaesth

Acetaminophen pharmacokinetics in infants and children with congenital heart disease.


Holladay J, Winch P, Morse J, Anderson BJ, McKee CT, Rice-Weimer J, Tobias JD
Paediatr Anaesth. 2022 Oct 20.
PMID: 36264219.


Acetaminophen is routinely used for perioperative analgesia in children undergoing major surgical procedures. There are few estimates of acetaminophen pharmacokinetic parameters in children with congenital heart disease, especially those with cyanotic heart disease.