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Papers of the Week

Papers: 15 Oct 2022 - 21 Oct 2022

2022 Oct 18

Discov Oncol



Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials.



Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. In this review, we address mechanisms underpinning the pathobiology of metastatic prostate cancer induced bone pain (PCIBP) that include sensitization and sprouting of primary afferent sensory nerve fibres in bone. We also review current treatments and pain responses evoked by various treatment modalities in clinical trials in this patient population.