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Papers of the Week

2022 Oct

J Dent Anesth Pain Med



Propofol protects against lipopolysaccharide-induced inflammatory response in human amnion-derived WISH cells.


Kim C-H, Lee S-H, Yoon J-Y, Kim E-J, Joo J H, Kim Y H, Choi E-J
J Dent Anesth Pain Med. 2022 Oct; 22(5):369-376.
PMID: 36246037.


Nonobstetric surgery is sometimes required during pregnancy, and neck abscess or facial bone fracture surgery cannot be postponed in pregnant women. However, dental surgery can be stressful and can cause inflammation, and the inflammatory response is a well-known major cause of preterm labor. Propofol is an intravenous anesthetic commonly used for general anesthesia and sedation. Studies investigating the effect of propofol on human amnion are rare. The current study investigated the effects of propofol on lipopolysaccharide (LPS)-induced inflammatory responses in human amnion-derived WISH cells.