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Papers of the Week

2022 Sep

Transl Lung Cancer Res



Cytokine release syndrome in a patient with non-small cell lung cancer on ipilimumab and nivolumab maintenance therapy after vaccination with the mRNA-1273 vaccine: a case report.


Sumi T, Koshino Y, Michimata H, Nagayama D, Watanabe H, Yamada Y, Chiba H
Transl Lung Cancer Res. 2022 Sep; 11(9):1973-1976.
PMID: 36248324.


Cytokine release syndrome (CRS) is caused by the release of inflammatory cytokines that appear during or immediately after administration of a therapeutic antibody and can cause a variety of symptoms. COVID-19 vaccination is effective in cancer patients and prevents breakthrough infections. The safety of vaccines during immune checkpoint inhibitor (ICI) therapy has been reported; however, multiple vaccinations have been developed in recent years, and it is unclear whether repeated vaccinations play a role in the development of CRS in patients receiving ICI.