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Papers of the Week

2022 Oct 14

Life Sci

A receptor-induced overexpression of pannexin-1 channels indirectly mediates adenosine fibrogenic actions by favouring ATP release from human subcutaneous fibroblasts.


Herman-de-Sousa C, Costa M A, Silva R P, Ferreirinha F, Ribeiro S, Correia-de-Sá P
Life Sci. 2022 Oct 14:121080.
PMID: 36252698.


Disorganization of the subcutaneous tissue due to inflammation and fibrosis is a common feature in patients with myofascial pain. Dermal accumulation of adenosine favours collagen production by human subcutaneous fibroblasts (HSCF) via A receptors (AR) activation. Adenosine mimics the fibrogenic effect of inflammatory mediators (e.g. histamine, bradykinin), which promote ATP release from HSCF via plasma-membrane-bound pannexin-1 (Panx1) and/or connexin-43 (Cx43) channels, but this mechanism has never been implicated in AR actions.