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Papers of the Week

2022 Oct 11

Rev Esp Anestesiol Reanim (Engl Ed)

Role of vortioxetine in the treatment of neuropathic pain.


Alcántara Montero A, Pacheco de Vasconcelos SR
Rev Esp Anestesiol Reanim (Engl Ed). 2022 Oct 11.
PMID: 36241510.


Neuropathic pain is an important and disabling clinical problem, its management constitutes a challenge for healthcare professionals. Vortioxetine is a new antidepressant drug with multimodal action, which gives it a unique profile. Tricyclic antidepressants, in particular amitriptyline, and serotonin and norepinephrine reuptake inhibitors venlafaxine and duloxetine are first-line drugs in the treatment of neuropathic pain. The interaction between the pain and depression binomial is very frequent, being the most frequent psychological complication in patients with chronic pain. This comprehensive and descriptive review summarizes the most relevant pharmacological data on vortioxetine, as well as the specific literature on vortioxetine in neuropathic pain and chronic pain.